In this present work, fast dissolving tablets of charantin were prepared by direct compression method to minimize bitter taste and to reduce first pass hepatic metabolism. Three superdisintegrants, viz., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios (5% and 10%) along with beta cyclodextrin, microcrystalline cellulose, Saccharin sodium were used. Saccharin sodium used as effective taste masking agent. The various precompression parameters were determined for the powder blend and the prepared batches of tablets were evaluated for hardness, friability, weight variation, wetting time, water absorption ratio, in-vitro disintegration time and in-vitro dissolution time. IR studies indicates that no interaction between drug and excipients. Short term stability studies on the formulations also indicates that no physical or chemical changes in the formulations during the study period.
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